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尽管化学治疗迅速发展,但许多化疗药物不易透过血脑屏障,使中枢神经系统(CNS)成为白血病细胞的第一庇护所,中枢神经系统白血病(CNSL)成为急性淋巴细胞白血病(ALL)患儿复发的最重要原因。我们对1986～1996年收治的363例ALL患儿随访观察2年,结果表明:鞘注MTX、Ara-C、Dx加静滴HD-MTX可明显降低CNSL的发生率,对提高ALL患儿的持续完全缓解率(CCR)有着十分重要的意义;而且副作用少、安全可靠,适用于基层医疗单位开展。
Despite rapid advances in chemotherapy, many chemotherapeutics do not readily cross the blood-brain barrier, making the central nervous system (CNS) the first refuge for leukemic cells and central nervous system leukemia (CNSL) to become acute lymphoblastic leukemia (ALL) The most important reason for recurrence. We observed 363 children with ALL who were treated from 1986 to 1996 and followed up for 2 years. The results showed that intrathecal injection of MTX, Ara-C and Dx plus intravenous injection of HD-MTX can significantly reduce the incidence of CNSL, Continuous complete response rate (CCR) has very important significance; and less side effects, safe and reliable, suitable for primary health care units.