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目的:蛋白在垂体腺瘤中表达,探讨抗白细胞分化抗原(Clusterofdiffer-entiation)CD34单抗标记的微血管密度(Mi-crovascularDensity,MVD)与垂体腺瘤分级的关系及其临床意义,对患者选择更有效和安全有利于患者社会生活的治疗手段提供理论依据。方法:采用免疫组化SP法对1998-05/2001-0741例垂体腺瘤组织及5例正常垂体组织中CD34的表达进行检测。结果:41例垂体腺瘤组织中平均MVD为20.9±8.0,5例正常垂体组织的平均MVD为12.2±2.4,二者差异具有显著性意义(t=2.4.P<0.05)。其中平均MVD(个/高倍视野)值在23例侵蚀型垂体腺瘤组(Ⅲ～Ⅴ级)为27.0±4.8,在18例封闭型垂体组织(Ⅰ～Ⅱ级)为13.2±2.6,侵蚀型垂体腺瘤组的平均MVD与封闭型垂体腺瘤组和正常垂体组织组之间的差异均有显著性(t=10.9,P<0.01)。而封闭型垂体腺瘤组和正常垂体组织组平均MVD的之间差异无显著性意义(P>0.05)。结论:抗CD34单抗标记的肿瘤微血管密度与垂体腺瘤的临床分级密切相关,可反映垂体腺瘤侵袭性行为的使用指标,以指导临床医生选择更为切实、安全及对患者生理、心理、精神和主观感受都有益处的治疗方案。
Objective: To investigate the relationship between the expression of CD34 monoclonal antibody (MVD) and pituitary adenoma in patients with pituitary adenoma and its clinical significance. Effective and safe for the treatment of patients with social life to provide a theoretical basis for treatment. Methods: The expression of CD34 in pituitary adenomas from 1998-05 / 2001-0741 and in 5 normal pituitary tissues was detected by immunohistochemical SP method. Results: The average MVD in 41 cases of pituitary adenomas was 20.9 ± 8.0. The mean MVD of 5 cases of normal pituitary tissues was 12.2 ± 2.4. The difference was significant (t = 2.4, P <0.05). The mean MVD (a / high power field) value was 27.0 ± 4.8 in 23 cases of erosive pituitary adenomas (group Ⅲ ~ Ⅴ) and 13.2 ± 2.6 in 18 cases of closed pituitary tissues (type Ⅰ ~ Ⅱ) There was significant difference between the average MVD in pituitary adenomas and the group of closed pituitary adenomas and normal pituitary adenomas (t = 10.9, P <0.01). There was no significant difference between the average MVD of closed pituitary adenoma group and normal pituitary tissue group (P> 0.05). Conclusion: The anti-CD34 monoclonal antibody-labeled microvessel density is closely related to the clinical grade of pituitary adenoma and may reflect the use of invasive behavior of pituitary adenomas in order to guide clinicians to choose more practical and safe and to the patient’s physiological, psychological, Mental and subjective feelings are beneficial treatment programs.