目前已经有越来越多的资料显示,性别的生理差异是造成药物不同反应的主要原因。一般来说,男性体型高大,肌肉含量较多;而女性则身材较小,脂肪含量偏高。这就使进入体内的药物与蛋白的结合率产生了差异。蛋白结合率较高的药物,通常药效的作用时间也较长,因此,男女体型上的差别也就间接导致了药效持续时间的不同。 At present, more and more data have shown that the physiological differences in sex are the main reasons for the different reactions of drugs. In general, men are tall and muscular, while women are smaller and have higher fat. This makes the difference between the rate of drug and protein entry into the body. Drugs with higher protein binding rate, usually the role of drug efficacy is also longer, therefore, the difference between the body size of men and women also indirectly led to different duration of efficacy.