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目的观察比较鼓室内注射甲基泼尼松龙与地塞米松治疗难治性突发性耳聋的临床效果。方法选取医院收治的66例难治性耳聋患者,按数字表法随机分为观察组和对照组,每组33例。2组患者均给予微循环优化、营养神经等常规治疗。在常规治疗基础上,观察组给予鼓室内注射甲基泼尼松龙治疗,对照组鼓室内注射地塞米松治疗,比较2组患者临床疗效、各频率听力改善情况及不良反应发生情况。结果观察组总有效率为90.9%,对照组总有效率为81.8%,2组比较差异无统计学意义(P>0.05)。2组在0.5、1、3 k Hz听阈的改善幅度无明显差异,观察组在4、8 k Hz听阀的改善幅度明显优于对照组(P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论鼓室内注射甲基泼尼松龙治疗难治性突发性耳聋效果较好,且安全性高,值得临床推广。
Objective To compare the clinical effects of intratympanic methylprednisolone and dexamethasone in the treatment of refractory sudden deafness. Methods Totally 66 patients with refractory deafness admitted in hospital were randomly divided into observation group and control group according to the digital table method, with 33 cases in each group. Two groups of patients were given microcirculation optimization, nutritional nerves and other conventional treatment. On the basis of routine treatment, the observation group received intramuscular injection of methylprednisolone, while the control group received intrathecal injection of dexamethasone. The clinical efficacy, frequency of hearing improvement and adverse reactions in the two groups were compared. Results The total effective rate was 90.9% in the observation group and 81.8% in the control group. There was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups in improving the hearing threshold at 0.5, 1, 3 Hz. The improvement amplitude of the hearing valve at 4 and 8 k Hz in the observation group was significantly better than that in the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Intra-tympanic injection of methylprednisolone is effective in treatment of refractory and sudden deafness, and it is safe and worthy of clinical promotion.