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目的通过研究101例HIV/HCV共感染患者念珠菌检出情况,分析其可能的相关因素.方法采集101例HIV/HCV共感染患者口腔、皮肤、指甲标本,采用CHROMagar念珠菌显色培养基培养、45℃生长试验及API-20C-AUX鉴定系统鉴定到种,同时进行单因素和多因素分析.结果 101例HIV/HCV共感染患者中有44例(43.6%)检出念珠菌,所分离到的44株念珠菌中,有19株白念珠菌(43.2%),9株近平滑念珠菌(20.5%),8株季也蒙念珠菌(18.2%),1株为热带念珠菌(2.3%),1株克柔念珠菌(2.3%),5株涎沫假丝酵母菌(11.4%),1株产朊假丝酵母(2.3%).通过单因素和多因素分析发现:该人群念珠菌检出率的CD4计数、病毒载量比较差异具有统计学意义(P<0.01).结论 HIV/HCV共感染患者念珠菌主要菌种是白念珠菌、近平滑念珠菌和季也蒙念珠菌;检出率与CD4计数、病毒载量高度相关;检出率可能对HIV/HCV共感染患者判断临床预后有一定参考价值.
Objective To investigate Candida albicans detection in 101 co-infected patients with HIV / HCV and analyze its possible related factors.Methods 101 samples of oral cavity, skin and nails from HIV / HCV co-infected patients were collected and cultured with Candida albicans chromogenic medium , 45 ℃ growth test and API-20C-AUX identification system.And single factor and multivariate analysis were performed at the same time.Results Forty-four cases (43.6%) of 101 HIV / HCV co-infected patients were detected Candida, isolated Among the 44 strains of Candida, 19 Candida albicans (43.2%), 9 Candida parapsilosis (20.5%), Candida albicans (18.2%) and Candida tropicalis Candida albicans (11.4%) and Candida utilis (2.3%). One-way and multi-factor analysis showed that the population Candida albicans detection rate of the CD4 count, the viral load was statistically significant difference (P <0.01) .Conclusion HIV / HCV co-infection in Candida albicans Candida albicans, Candida parapsilosis The detection rate was highly correlated with CD4 count and viral load. The detection rate may have some reference value for judging the clinical prognosis of HIV / HCV co-infected patients.