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目的研究乳酸脱氢酶(LDH)、羟丁酸脱氢酶(HBDH)在巨幼细胞性贫血(MA)中的意义。方法选择临床诊断明确的MA74例,检测血常规、叶酸、维生素B12(VitB12)、总胆红素、间接胆红素、LDH、HBDH等。结果MA患者LDH、HBDH、胆红素较对照组显著上升(P<0.01),LDH与HBDH成正相关,与白细胞(WBC)、血红蛋白(Hb)、血小板(Plt)成负相关,与红细胞体积(MCV)、红细胞平均血红蛋白(MCH)、红细胞平均血红蛋白浓度(MCHC)、胆红素、叶酸、VitB12无关。给予叶酸和VitB12治疗后LDH、HBDH、胆红素明显下降。结论LDH和HBDH可作为MA严重程度的指标,可作为治疗是否有效的指标,可作为各种贫血的鉴别要点。
Objective To study the significance of lactate dehydrogenase (LDH) and hydroxybutyrate dehydrogenase (HBDH) in megaloblastic anemia (MA). Methods MA74 cases with definite clinical diagnosis were selected and tested for blood routine, folic acid, vitamin B12 (VitB12), total bilirubin, indirect bilirubin, LDH, HBDH and so on. Results The levels of LDH, HBDH and bilirubin in MA patients were significantly higher than those in control group (P <0.01). LDH was positively correlated with HBDH and negatively correlated with WBC, Hb and Plt, MCV, MCH, MCHC, bilirubin, folic acid, and VitB12. Given folic acid and VitB12 treatment LDH, HBDH, bilirubin significantly decreased. Conclusion LDH and HBDH can be used as indicators of the severity of MA, can be used as an indicator of the effectiveness of treatment, can be used as a differential point of various anemia.