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目的观察真武汤加味治疗阳虚水泛型慢性心力衰竭(CHF)的临床疗效。方法将60例CHF患者随机分为治疗组与对照组,各30例;对照组采用西医常规治疗,治疗组采用西医常规结合真武汤加味治疗,疗程14天。观察两组临床疗效、证候积分、彩色超声心动图指标、脑钠肽(BNP)变化。结果治疗组的临床疗效优于对照组(P<0.05);治疗后两组左室射血分数(LVEF)、每搏输出量(SV)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)均有明显改善(P<0.05,P<0.01),且治疗组的改善优于对照组(P<0.05);治疗后两组血浆BNP水平显著降低(P<0.01),且治疗组低于对照组(P<0.05)。结论真武汤加味可以改善慢性心力衰竭患者心脏功能、降低BNP水平。
Objective To observe the clinical efficacy of Zhenwu Decoction in the treatment of Yang deficiency water-induced chronic heart failure (CHF). Methods Sixty patients with CHF were randomly divided into treatment group and control group, with 30 cases in each group. The control group was treated with conventional western medicine. The treatment group was treated with western medicine and Zhenwu Decoction. The course of treatment was 14 days. Clinical efficacy, syndrome score, color echocardiography and BNP were observed. Results The clinical efficacy of the treatment group was better than that of the control group (P <0.05). After treatment, LVEF, SV, LVEDV, (P <0.05, P <0.01), and the improvement in the treatment group was better than that in the control group (P <0.05). After treatment, the levels of plasma BNP in the two groups were significantly decreased (P <0.01) Group lower than the control group (P <0.05). Conclusions Zhenwu decoction can improve cardiac function and reduce BNP level in patients with chronic heart failure.