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以羟丙基甲基纤维素为骨架制备了水凝胶型头孢克罗缓释片 ,以体外释药试验筛选处方 ,制得的缓释片体外释药规律符合Higuchi方程。同时考察了不同的试验方法对头孢克罗缓释片体外释药的影响 ,为进一步进行释药影响因素考察打下基础。
Hydroxypropylmethylcellulose was used as matrix to prepare hydrogel-type cefaclor sustained-release tablets. The in vitro drug release test was used to screen the prescriptions. The sustained-release tablets prepared in vitro were in accordance with the Higuchi equation. At the same time, the influence of different test methods on the in vitro release of cefaclor sustained-release tablets was investigated, laying a foundation for the further study on the factors influencing drug release.