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作者对12例串珠菌感染的病人,服用一种克霉唑锭,进行双盲法研究,以考察克霉唑对口腔串珠菌病的局部效果。病人的年龄4～65岁,女性7例,不包括孕妇,男性5例,病程最短一年,最长40年。真菌学检查证实为口腔(粘膜皮肤)串珠菌病。用其他局部或全身性抗真菌或抗菌素治疗的患者不作为试治对象。6例给10毫克的锭剂,另6例给50毫克的锭剂,每天10次,治疗14天。锭剂不咀嚼,在口内含化,使药物浸润到整个口咽部。治疗后1周、2周和4周进行随访。对结果的评价标准是:优良——临床症状消失,真菌培养阴性;良好——临床症状有改进,真菌培养阴性;较好——临床有改进,真菌培养还阳性,但菌落有减少;无反应——临床、真菌学均无改进。
The authors investigated 12 local effects of clotrimazole on oral candidiasis in 12 patients with streptozotocin-infected patients taking a clotrimazole in a double-blind study. Patients aged 4 to 65 years, 7 females, excluding pregnant women, 5 males, the shortest duration of one year, up to 40 years. Mycological examination confirmed oral (mucocutaneous) streptozotocosis. Patients treated with other topical or systemic antifungal or antibiotics are not treated as subjects. 6 cases to 10 mg tablets, the other 6 cases to 50 mg tablets, 10 times a day for 14 days. Tablets do not chew, containing in the mouth, the drug infiltrates the entire oropharyngeal. One week, two weeks and four weeks after treatment were followed up. The criteria for evaluation of the results were: Good - disappearance of clinical symptoms, negative fungal culture; good - improvement of clinical symptoms, negative of fungal culture; better - clinical improvement, positive fungal culture but less colony; no response - Clinical, mycological no improvement.