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英国自60年代中期广泛使用口服避孕药(OC),大部分于周期第5天开始服药,并于周期的前14天内加用其他避孕措施。推荐从周期第5天开始服药的理由,主要由于历史的原因,而并无科学依据。因为在OC发展早期,考虑到如果于周期第1天开始服药会影响月经,若开始服药迟则有可能不能抑制排卵。近年来医生和计划生育工作者主张于周期第1天开始服药,以达到早期避孕目的,且可免于使用其他的避孕措施。然而尚无于周期第1天和周期第5天服药对排卵抑制的生化证据。为此作者比较了于周期第1天开始服药和周期第5天开始服药的妇女的激素变化。研究包括14例妇女,年龄17～32岁,无使用复合型OC的禁忌症,受试前6个月
Oral contraceptives (OCs) are widely used in the United Kingdom since the mid-1960s and most often start on the fifth day of the cycle. Additional contraceptives are added within the first 14 days of the cycle. The rationale for recommending medication from the fifth day of the cycle is mainly due to historical reasons and no scientific basis. Because in the early development of OC, taking into account if the first day of the cycle began to take medication will affect menstruation, if started later may not inhibit ovulation. In recent years, doctors and family planning workers have advocated starting medication on the first day of the cycle in order to achieve early contraception and avoid the use of other contraceptive measures. However, there is no biochemical evidence of ovulation inhibition on day 1 of the cycle and on day 5 of the cycle. To this end, the authors compared the hormonal changes in women who started their medications on day 1 of the cycle and started on day 5 of the cycle. The study included 14 women aged 17-32 years with no contraindication to combined OC, 6 months prior to study