作者在8年前瞻性随访中,对684例经病理证实的慢性乙型肝炎病人发展成肝硬化的发病率与诱发因素进行了前瞻性的分析。其中列入研究的有509例HB_3Ag阳性及175例抗HBe阳性病人平均随访时间为35.3个月,6～64个月后,在HBsAg阳性病人中有35例,抗HBe阳性病人中有7例发生肝硬化,推算每年发生率分别为2.4％和1.3％(P>0.05)。发病率随 In a prospective 8-year follow-up, the authors prospectively analyzed the incidence and the prevalence of cirrhosis in 684 patients with pathologically confirmed chronic hepatitis B. Of the 509 HB-3Ag-positive and 175-anti-HBe-positive patients included in the study, the mean follow-up was 35.3 months. Six to 64 months later, 35 of HBsAg-positive patients and 7 of anti-HBe-positive patients The annual incidence of cirrhosis is estimated to be 2.4% and 1.3%, respectively (P> 0.05). With the incidence