早在上世纪 4 0年代 ,细胞毒性药物已广泛应用于癌症的化疗 ,这些药物对癌细胞和人体健康细胞的非特异性 ,使它在杀伤癌细胞的同时 ,产生全身严重的毒副作用。脂质体、毫微粒、微球和脂质微球等靶向释药系统的发展 ,改变了药物在肿瘤组织与非肿瘤组织的分布 ,使体内蓄积毒性降 As early as 40 years in the last century, cytotoxic drugs have been widely used in cancer chemotherapy, these drugs on cancer cells and human non-specific health cells, making it in the killing of cancer cells at the same time, have serious systemic side effects. The development of targeted drug delivery systems such as liposomes, nanoparticles, microspheres and lipid microspheres has changed the distribution of drugs in tumor tissues and non-tumor tissues, resulting in the accumulation of toxic substances in the body