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在细胞永生化和肿瘤发展过程中 ,端粒酶的激活是一个关键性的步骤。人类端粒酶逆转录酶 (hTERT)基因的表达是端粒酶激活的限速步骤。现综述hTERT基因启动子介导肿瘤凋亡的最新研究进展。
Activation of telomerase is a crucial step in cell immortality and tumor development. Human telomerase reverse transcriptase (hTERT) gene expression is the rate-limiting step in telomerase activation. The latest research progress of hTERT gene promoter-mediated tumor apoptosis is summarized.