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对补骨脂盐炙新法制品同老法制品作了药效和毒性的比较研究。新法制品的升白作用优于老法制品;在止泻和对性器官重量的影响上,两者无显著差异。新法制品灌胃LD50及对肾组织的损伤等毒性上则小于老法制品。结果提示本工艺改进有助于增效、减毒。
A comparative study on pharmacodynamics and toxicity of psoralen salt, new method products and old method products was conducted. The whitening effect of the new product was better than that of the old product; there was no significant difference in the effects of diarrhea and the weight of sexual organs. The new method products are less toxic than the old method products such as gavage LD50 and damage to kidney tissue. The results suggest that this process improvement will help increase efficiency and reduce toxicity.