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已经知道雌二醇可以引起c-myc原癌基因在大鼠子宫迅速和短暂的表达。我们的研究证实了雌二醇可以引起c-myc 原癌基因在切除卵巢大鼠的子宫表达,并且观察到一种抗雌激素—三苯氧氨(Tamoxifen)对c-myc 在子宫表达无明显作用,但它却能抑制雌二醇引起c-myc 增加的表达。
It is known that estradiol causes rapid and transient expression of the c-myc oncogene in the rat uterus. Our study confirms that estradiol causes the expression of the c-myc oncogene in the uterus of ovariectomized rats and that an anti-estrogen-Tamoxifen was observed to have no significant effect on c-myc expression in the uterus But it inhibits estradiol-induced increased c-myc expression.