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目的应用磁共振成像(MRI)对颈动脉粥样斑块检测,研究不同性质斑块的MRI影像学表现及其特征并应用MRI对比阿托伐他汀治疗前后颈动脉粥样斑块的变化,探讨其对动脉粥样硬化的治疗作用。方法选择2006年12月至2008年5月在该院住院经超声证实有颈动脉粥样硬化斑块患者50例,所有患者均予阿托伐他汀治疗,治疗前后均行颈动脉MRI检测斑块大小、性质、组成成分。结果不稳定斑块组斑块平均厚度消减明显(P<0.05),稳定斑块组的斑块平均厚度治疗前后差异无统计学意义(P>0.05)。斑块的分型由不稳定型斑块向稳定型斑块转化。结论阿托伐他汀对颈动脉粥样斑块有消退作用,MRI是一种很有潜力的检测斑块性质和组成的检测手段。
Objective To detect the carotid atherosclerotic plaques by using magnetic resonance imaging (MRI), to study the MRI features of different plaques and to compare the changes of carotid plaques before and after treatment with atorvastatin Its therapeutic effect on atherosclerosis. Methods Fifty patients with carotid atherosclerotic plaque confirmed by ultrasound in hospital from December 2006 to May 2008 were selected. All patients were treated with atorvastatin. Carotid artery MRI was used to detect the plaque before and after treatment Size, nature, composition. Results The average plaque thickness in the unstable plaque group was significantly reduced (P <0.05). There was no significant difference in mean plaque thickness between the stable plaque group before and after treatment (P> 0.05). Plaque classification from unstable to stable plaque transformation. Conclusions Atorvastatin has a regressive effect on carotid artery plaque. MRI is a potential test method to detect the nature and composition of plaque.