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目的探讨硝苯地平联合黄芪注射液对妊娠期高血压疾病患者同型半胱氨酸(Hcy)、胱抑素(Cys C)水平的影响。方法将120例妊娠期高血压疾病患者随机分为观察组及对照组,每组各60例。对照组每天舌下含服硝苯地平,观察组在对照组基础上应用黄芪注射液静脉滴注治疗,对比分析两组患者临床治疗效果、不良妊娠结局及治疗前后血清Hcy、Cys C水平变化。结果观察组总有效率为98.33%,对照组总有效率为86.67%(P<0.05)。观察组治疗后收缩压(SBP)、舒张压(DBP)、血液黏稠度、24 h尿蛋白定量水平显著低于对照组(P<0.05)。观察组治疗后血清Hcy、Cys C水平低于对照组(P<0.05)。观察组产后出血、胎盘早剥、胎儿窘迫、新生儿窒息显著低于对照组(P<0.05)。结论硝苯地平与黄芪注射液联合应用可妊娠期高血压疾病患者治疗效果,其作用机制可能是通过调整血清Hcy、Cys C水平,从而达到降低血压,减轻尿蛋白,降低不良妊娠结局的作用。
Objective To investigate the effect of nifedipine combined with astragalus injection on the levels of homocysteine (Hcy) and cystatin (Cys C) in patients with hypertensive disorder complicating pregnancy. Methods 120 patients with gestational hypertension were randomly divided into observation group and control group, 60 cases in each group. The control group was treated sublingually with nifedipine subcutaneously. The observation group was treated with intravenous injection of Astragalus injection on the basis of the control group. The clinical effects, adverse pregnancy outcomes and changes of serum Hcy and Cys C levels before and after treatment were compared between the two groups. Results The total effective rate was 98.33% in the observation group and 86.67% in the control group (P <0.05). After treatment, SBP, DBP, blood viscosity and 24 h urinary protein levels in observation group were significantly lower than those in control group (P <0.05). The levels of Hcy and Cys C in the observation group were lower than those in the control group (P <0.05). The observation group postpartum hemorrhage, placental abruption, fetal distress, neonatal asphyxia was significantly lower than the control group (P <0.05). Conclusion Nifedipine combined with astragalus injection can be used in treatment of patients with gestational hypertension, its mechanism may be through the adjustment of serum Hcy, Cys C levels, so as to reduce blood pressure, reduce urinary protein, reduce adverse pregnancy outcomes.