细胞凋亡是一种不同于细胞坏死的死亡形式,是受基因调控的细胞主动性“自杀”过程。自1972年Kerr等首次提出细胞凋亡的概念以来,细胞凋亡的研究不断深入。大量研究表明细胞凋亡参与了多种疾病的发生发展。近年来又发现动脉粥样硬化(AS)斑块中存在着多种细胞的凋亡与坏死,如内皮细胞、平滑肌细胞、巨噬细胞,而凋亡占其主导地 Apoptosis is a form of death that is distinct from cell necrosis and is a genetically controlled cellular initiative “suicide ” process. Since the concept of apoptosis was proposed by Kerr et al. In 1972 for the first time, the research on apoptosis has been deepening. A large number of studies have shown that apoptosis is involved in the development of many diseases. In recent years, it has been found that there are many kinds of apoptosis and necrosis of cells in atherosclerotic plaque, such as endothelial cells, smooth muscle cells and macrophages, and apoptosis predominates