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目的：探讨白细胞介素－８（ＩＬ－８）及白细胞介素－１６（ＩＬ－１６）在慢性阻塞性肺疾病（ＣＯＰＤ）气道炎症中的作用。方法：采用酶联免疫吸附法（ＥＬＩＳＡ）检测收集到的ＣＯＰＤ患者急性发作期及正常人的痰ＩＬ－８及ＩＬ－１６水平。结果：ＣＯＰＤ患者急性发作期痰ＩＬ－８及ＩＬ－１６水平明显高于正常对照组的水平（Ｐ＜０．０５），ＣＯＰＤ患者痰液ＩＬ－８与ＦＥＶ１呈负相关（ｒ＝－０．６７，Ｐ＜０．０１），其痰ＩＬ－１６亦与ＦＥＶ１呈负相关（ｒ＝－０．４５，Ｐ＜０．０５）。结论：ＣＯＰＤ患者痰液ＩＬ－８及ＩＬ－１６均参与了ＣＯＰＤ的发病过程，而且以ＩＬ－８所起的作用最为主要。
Objective: To investigate the role of interleukin-8 (IL-8) and interleukin-16 (IL-16) in airway inflammation in patients with chronic obstructive pulmonary disease (COPD). Methods: The sputum IL-8 and IL-16 levels of sputum from acute exacerbation and normal subjects were detected by enzyme-linked immunosorbent assay (ELISA). Results: The levels of IL-8 and IL-16 in sputum of patients with acute exacerbation of COPD were significantly higher than those of normal controls (P <0.05). IL-8 in sputum of COPD patients was negatively correlated with FEV1 (r = -0. 67, P <0.01). The sputum IL-16 also had a negative correlation with FEV1 (r = -0.45, P <0.05). CONCLUSIONS: Both sputum IL-8 and IL-16 in COPD patients are involved in the pathogenesis of COPD, and IL-8 plays a major role.