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目的观察缬沙坦并氢氯噻嗪对老年单纯收缩期高血压(ISH)的降压作用及对脉压(PP)和左室肥厚(LVH)的影响。方法67例ISH患者给予缬沙坦并氢氯噻嗪口服16周,治疗前及治疗后每2周测量血压,治疗前后查超声心动图,测量左室舒张末内径(LVDd)、室间隔厚度(IVST)及左室后壁厚度(PWT),计算左室重量指数(LVM I),观察治疗前后血压、PP、LVM I的变化。结果治疗后收缩压(SBP)、PP显著降低(P<0.01),舒张压(DBP)明显降低(P<0.05),左室重量指数(LVM I)显著下降(P<0.01)。结论缬沙坦并氢氯噻嗪能显著降低SBP、PP、LVM I,改善左室重塑肥厚。
Objective To observe the antihypertensive effects of valsartan and hydrochlorothiazide on senile isolated systolic hypertension (ISH) and its effects on pulse pressure (PP) and left ventricular hypertrophy (LVH). Methods Sixty-seven ISH patients were given oral valsartan and hydrochlorothiazide for 16 weeks. Before and after treatment, blood pressure was measured every two weeks. Echocardiography was performed before and after treatment. Left ventricular end-diastolic diameter (LVDd), interventricular septum thickness (IVST) Left ventricular posterior wall thickness (PWT), left ventricular mass index (LVM I), before and after treatment to observe changes in blood pressure, PP, LVM I. Results After treatment SBP, PP significantly decreased (P <0.01), diastolic blood pressure (DBP) decreased significantly (P <0.05) and LVM I decreased significantly (P <0.01). Conclusion Valsartan combined with hydrochlorothiazide can significantly reduce SBP, PP, LVM I, improve left ventricular remodeling.