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本文用改良酶学法测定20例宫内窘迫及出生时窒息的新生儿脐血浆次黄嘌呤（Hypoxanthine－Hx）水平，同时作Apgar评分，血气分析、电解质测定及临床观察。以18例正常新生儿为对照。结果显示：缺氧组新生地血浆Hx和Pco2明显高于对照组，而pH、PO2、氧含量（O2CT）、HCO3-明显低于对照组。Hx与Pco2呈正相关；与pH、PO2、HCO3-、O2CT是负相关；与Apgar评分呈负相关；与电解质变化的相关性符合缺氧后的改变。表明Hx参与缺氧损害过程，Hx能较客观、准确的反映组织细胞缺氧、酸中毒及能量代谢状况。
In this paper, 20 cases of intrauterine distress and neonatal asphyxia newborn umbilical plasma hypoxanthine (Hypoxanthine-Hx) levels were determined by modified enzymology method, Apgar score, blood gas analysis, electrolyte determination and clinical observation. 18 normal newborns as a control. The results showed that the plasma Hx and Pco2 concentrations in hypoxic group were significantly higher than those in control group, while the values of pH, PO2, oxygen content (O2CT) and HCO3- were significantly lower than those in control group. Hx was positively correlated with Pco2, negatively correlated with pH, PO2, HCO3- and O2CT, negatively correlated with Apgar score, and the correlation with electrolyte changes was consistent with changes after hypoxia. Hx is involved in hypoxia damage process, Hx can objectively and accurately reflect the hypoxia, acidosis and energy metabolism of tissue cells.