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目的:研究梅花钻对乙醇引起肝损伤的保护作用。方法:将昆明种小鼠分为正常对照组、乙醇模型组、梅花钻(33.40,16.70,8.35 g·kg-1)剂量组,观察各组小鼠血清的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、谷胱甘肽S-转移酶(GST)、超氧化物歧化酶(SOD)活性和肝匀浆中的丙二醛(MDA)、甘油三酯(TG)的含量,评价梅花钻对肝损伤的保护作用。结果:梅花钻高、中剂量组与乙醇模型组比较,ALT,AST,GST,MDA,TG降低(P<0.05或P<0.01),SOD明显升高(P<0.01)。结论:梅花钻对小鼠乙醇引起的肝损伤有保护作用。
Objective: To study the protective effect of plum blossom on liver injury induced by ethanol. METHODS: Kunming mice were divided into normal control group, ethanol model group and plum blossom drill (33.40, 16.70, 8.35 g·kg-1) dose groups. Serum alanine aminotransferase (ALT) and ALT were observed in each group. Aspartate aminotransferase (AST), glutathione S-transferase (GST), superoxide dismutase (SOD) activity and malondialdehyde (MDA), triglyceride (TG) content in liver homogenates , To evaluate the protective effect of plum blossom on liver injury. RESULTS: Compared with ethanol model group, the ALT, AST, GST, MDA and TG of plum blossom drill high and medium dose groups were decreased (P<0.05 or P<0.01), and SOD was significantly increased (P<0.01). Conclusion: Plum drill has protective effect on ethanol-induced liver injury in mice.