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支气管哮喘(简称哮喘)是一种以气道高反应、嗜酸性粒细胞(EOS)浸润为主要特征的气道慢性非特异性炎症性疾病。大量研究发现哮喘黏液高分泌与慢性炎症和气道重塑有关,杯状细胞增生和黏液高分泌是哮喘气道重塑的特征之一。过量黏液产生、黏液清除力下降、黏液栓的形成,是重症患者发病与死亡率增加的主要原因[1]。现在哮喘黏液分泌机制研究主要集中在炎症介质如何导致慢性黏液高分泌方面,以往认为哮喘
Bronchial asthma (asthma) is a chronic airway non-specific inflammatory disease characterized by airway hyperresponsiveness and eosinophilic granulocyte (EOS) infiltration. A large number of studies have found that mucus hypersecretion in asthma is associated with chronic inflammation and airway remodeling. Goblet cell hyperplasia and mucus hypersecretion are one of the characteristics of asthma airway remodeling. Excessive mucus production, decreased mucus clearance, the formation of mucus plug, is an important cause of increased morbidity and mortality in critically ill patients [1]. Now asthma mucus secretion mechanism of research focused on how the inflammatory mediators cause chronic mucus hypersecretion, previously considered asthma