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目的评估小麦纤维素颗粒对2型糖尿病患者血糖和血脂的干预作用。方法将60例2型糖尿病患者随机分成观察组(n=30)和对照组(n=30),对照组接受降糖降脂方案治疗,观察组在对照组降糖降脂方案的基础上联合小麦纤维素颗粒治疗,疗程均为28 d,观察治疗前后两组空腹血糖(FPG)、餐后2 h血糖(2h-PG)和糖化血清白蛋白(GA),以及总胆固醇(TG)、甘油三脂(TC)、高密度脂蛋白-胆固醇(HDL-C)和低密度脂蛋白-胆固醇(LDL-C)等血脂各项指标的变化。结果糖代谢方面:与治疗前相比,观察组治疗后FPG、GA和2h-PG水平均明显降低,差异具有统计学意义(P<0.05或0.01),对照组FPG和2h-PG水平也明显降低,差异具有统计学意义(P<0.05)。组间比较表明,观察组2h-PG和GA水平降低更为显著,与对照组相比,差异具有统计学意义(P<0.05)。脂代谢方面:与治疗前相比,观察组治疗后LDL-C水平明显降低,差异具有统计学意义(P<0.05),对照组TC水平明显降低,差异具有统计学意义(P<0.05)。治疗后两组间血脂各项指标比较,差异无统计学意义(P>0.05)。两组均未出现严重不良反应及低血糖事件。结论小麦纤维素颗粒与降糖降脂药物联合治疗2型糖尿病,可改善患者血糖,并对血脂具有一定干预作用。
Objective To evaluate the effects of wheat cellulose granules on blood glucose and blood lipid in type 2 diabetic patients. Methods Sixty patients with type 2 diabetes mellitus were randomly divided into observation group (n = 30) and control group (n = 30). The control group was treated with hypoglycemic and lipid-lowering regimen. The observation group was combined with the hypoglycemic and lipid- The treatment course of wheat cellulose granules was 28 days. The levels of fasting blood glucose (FPG), 2h postprandial glucose (2h-PG), glycosylated serum albumin (GA), total cholesterol (TG) Triglyceride (TC), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) and other indicators of blood lipid changes. Results In terms of glucose metabolism, the levels of FPG, GA and 2h-PG in the observation group were significantly lower than those before treatment, the difference was statistically significant (P <0.05 or 0.01), and the levels of FPG and 2h-PG in the control group were also significantly higher Decreased, the difference was statistically significant (P <0.05). The comparison between groups showed that the level of 2h-PG and GA in observation group decreased more significantly than that in control group (P <0.05). In terms of lipid metabolism, the level of LDL-C in the observation group was significantly lower than that in the control group before treatment (P <0.05). The TC level in the control group was significantly lower (P <0.05). After treatment, the two groups of blood lipid indicators, the difference was not statistically significant (P> 0.05). No serious adverse reactions and hypoglycemic events occurred in both groups. Conclusion The combination of wheat cellulose granules and hypoglycemic and lipid-lowering drugs in the treatment of type 2 diabetes mellitus can improve blood sugar and have some intervention effects on blood lipids.