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目的：观察不同浓度的海风藤醇提取物（ＡＥＰＫ）对血小板活化因子（ＰＡＦ）诱导血小板聚集的拮抗作用。方法：于兔富含血小板血浆（ＰＲＰ）中分别加入海风藤醇提取物（ＡＥＰＫ），使后者达到不同的最终浓度；另设一份不加ＡＥＰＫ的对照ＰＲＰ。各份ＰＲＰ加入１０～－８ＭＯｌ浓度的ＰＡＦ并测血小板最大聚集率（ＭＡＲ），且加以对比。结果：所有加ＡＥＰＫ的ＰＲＰ，其ＭＡＲ都比对照ＰＲＰ的ＭＡＲ低，且ＡＥＰＫ浓度越高，ＭＡＲ越低。结论：海风藤醇提取物对ＰＡＦ诱导血小板聚集有剂量依赖性抑制作用。
OBJECTIVE: To observe the antagonistic effect of different concentrations of Aeolus japonicus (AEPK) on platelet aggregation factor (PAF)-induced platelet aggregation. METHODS: Apocylin extract (AEPK) was added to platelet-rich plasma (PRP) in rabbits to reach different final concentrations. A control PRP without AEPK was also set up. Each PRP was added with PAF at a concentration of 10 to -8 MOl and the platelet maximum aggregation rate (MAR) was measured and compared. RESULTS: All PRPs with AEPK had lower MAR than control PRP, and the higher the AEPK concentration, the lower the MAR. CONCLUSION: The extract of Erigeron brevis has a dose-dependent inhibitory effect on platelet aggregation induced by PAF.