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目的 :比较中药首乌、山楂、葛根合剂和苯扎贝特的调脂作用和安全性。方法 :13 8例病例随机分为A组 ( 3 4例 ) ,B组 ( 3 4例 )分别用中药合剂和苯扎贝特共 8周 ,C组用中药合剂 16周。用药前后比较TC、TG、HDL C和LDL、Lp(a)以及ox LDL。结果 :A、B两组总有效率分别为 91.16%及 97.0 5 % ,P >0 .0 5。A、C组显效率分别为 73 .5 2 %及 77.14 % ,P >0 .0 5。用药前后各组以上各项血脂自身前后对照P <0 .0 1。其中ox LDLA、B组分别下降 3 0 .95 %和 2 9.0 2 % ,A略优于B ,但P >0 .0 5。B组中有 2例出现一过性ALT升高 ,2例程度消化道反应。A组和C组无 1例有不良反应。结论 :中药调时抗氧化合剂有良好的抗ox LDL和调时作用 ,有利于抗动脉粥样硬化 ,防治冠心病 ,安全性好
Objective : To compare the lipid-regulating effect and safety of Chinese medicine Shouwu, Hawthorn, Pueraria mixture and bezafibrate. Methods: Eighteen cases were randomly divided into group A (34 cases), group B (34 cases) were treated with traditional Chinese medicine mixture and bezafibrate for 8 weeks, and group C was treated with traditional Chinese medicine mixture for 16 weeks. TC, TG, HDL C and LDL, Lp(a) and ox LDL were compared before and after administration. Results: The total effective rates of group A and group B were 91.16% and 97.05%, respectively. P>0.05. The significant rates in groups A and C were 73.52% and 77.14%, respectively, and P > 0.05. Before and after administration of each group of blood lipids before and after their own control P <0. The ox LDLA and B groups decreased by 30.95% and 29.02% respectively. A was slightly better than B, but P > 0.05. Two patients in group B had transient ALT elevation and 2 had severe gastrointestinal reactions. There was no adverse reaction in group A and group C. Conclusion : Chinese medicine anti-oxidation mixture has a good anti-ox LDL and timing effect, is conducive to anti-atherosclerosis, prevention and treatment of coronary heart disease, good safety