1968年 IgA 肾病首次被描述,最初称为 Berger 病。先证者为法国患儿,表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA 沉积,因此被命名为 IgA 肾病。此后40年临床治疗实践中,对该病自然病程了解逐渐增多,但对其发病机制知之甚少。20世纪80年代,D’Amico 和其他学者已经认识到 IgA 肾病是世界上最常见的肾小球肾炎。因此,Julian 等指出该病对1%以上的人口有影响。太平洋西岸国家如日本、新加坡、澳大利亚和新西兰,IgA 肾病占原发性肾小球肾炎肾活检标本的 IgA nephropathy was first described in 1968, initially as Berger’s disease. The proband was a French child with symptoms of asymptomatic gross hematuria after several days of acute upper respiratory infection. Renal biopsy showed a significant expansion of mesangial area, IgA deposition, it was named IgA nephropathy. After 40 years of clinical practice, the understanding of the natural history of the disease gradually increased, but its pathogenesis is poorly understood. In the 1980s, D’Amico and others learned that IgA nephropathy is the most common glomerulonephritis in the world. Therefore, Julian et al. Pointed out that the disease has an impact on more than 1% of the population. Pacific West Bank countries such as Japan, Singapore, Australia and New Zealand, IgA nephropathy accounts for primary glomerulonephritis in renal biopsy specimens