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丝裂霉素Ｃ（ｍｉｔｏｍｙｃｉｎＣ，ＭＭＣ）是一种常用的抗癌药物，其治疗指数较小，有时需进行血药浓度监测。用高效液相色谱（ＨＰＬＣ）法测定ＭＭＣ血药浓度多为提取法测定［１］，且因ＭＭＣ易分解，提取法会影响测定的准确性和精确性。本研究采用柱切换ＨＰＬＣ法...
Mitomycin C (MMC) is a commonly used anticancer drug with a small therapeutic index and sometimes blood concentration monitoring. High-performance liquid chromatography (HPLC) method for the determination of serum concentration of MMC mostly for the determination of the extraction method [1], and the MMC is easy to decompose, the extraction method will affect the accuracy and accuracy of the determination. This study uses column switching HPLC method ...