巯甲丙脯酸(Captopril)是一种口服的降压药,经抑制血管紧张素转化酶而起作用。该药副作用少,降压效果确切,特别是原发性高血压患者的良药。目前它已有片剂上市,也可能希望以糖浆、注射剂形式给药。本文就巯甲丙脯酸在水溶液中的稳定性进行讨论。巯甲丙脯酸含有巯基,易发生氧化,其酰胺基又易水解。金属化合物可促进氧化,而EDTA等金属螯合剂则可抑制氧化。将巯甲丙脯酸水溶液5mg/ml装入小瓶 Captopril is an oral antihypertensive drug that works by inhibiting angiotensin-converting enzyme. The drug side effects, antihypertensive effect is exact, especially in patients with essential hypertension medicine. It is available now on tablets, and may also want to be given in the form of syrups, injections. This article discusses the stability of captopril in aqueous solution. Captopril contains thiol, prone to oxidation, its amide group and easy hydrolysis. Metal compounds can promote oxidation, while metal chelators such as EDTA can inhibit oxidation. A 5 mg / ml captopril aqueous solution was placed in the vial