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报道了用硝苯地平（Ｎｆ）和聚乙烯吡咯烷酮（ＰＶＰ）制成固体分散体后滚制成Ｎｆ微丸的新工艺。Ｎｆ微丸与市售片剂的溶出度试验表明：其体外累积溶出百分率经０．５ｈ分别为８０％和≤５％，经Ｂｅａｇｌｅ犬口服两剂型的自身对照试验表明，微丸组犬体内血药达峰时明显加快（Ｔ＿（ｍａｘ）＝１ｈ），生物利用度也有显著提高。
A new process of rolling into Nf pellets by solid dispersion of nifedipine (Nf) and polyvinylpyrrolidone (PVP) was reported. The dissolution test of Nf pellets and the commercially available tablets showed that the cumulative dissolution percentage in vitro was 80% and ≤5% respectively in 0.5h, Significantly accelerated peak drug (T_ (max) = 1h), bioavailability also significantly increased.