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本文研究抗高血压药物治疗对５／６肾门除慢性肾衰ＳＤ大鼠的作用。所有大鼠随机分为四组，即正常对照组（Ｓｈａｍ）、５／６肾门除组（５／６Ｎｘ）、５／６肾切除＋依那普利组及５／６肾切除＋利血平、肼苯达嗪及双氢克尿噻三联抗高血压治疗组。结果示两种方法将血压控制在正常水平的条件下，５／６Ｎｘ大鼠尿蛋白排泄量、肾功能进行性恶化、肾小球面积及肾小球硬化病变均有不同程度的改善。提示抗高血压治疗一血管紧张素转换酶抑制剂或三联，除了具有降低残余肾小球毛细血管内静水压作用外，还可能通过抑制残余肾单位的代偿性肥大，而减少肾小球硬化，达到延缓慢性肾功能不全的目的。
This study was to investigate the effects of antihypertensives on 5/6 kidneys in rats with chronic renal failure. All rats were randomly divided into four groups: normal control group (Sham), 5/6 nephrectomy group (5 / 6Nx), 5/6 nephrectomy + enalapril group and 5/6 nephrectomy + Hydralazine and Hydrochlorothiazide triple antihypertensive treatment group. The results showed that the two methods to control blood pressure at normal conditions, 5 / 6Nx rat urinary protein excretion, progressive deterioration of renal function, glomerular area and glomerulosclerosis lesions have varying degrees of improvement. Tip anti-hypertensive treatment of an angiotensin-converting enzyme inhibitor or triple, in addition to reducing hydrostatic pressure within the residual glomerular capillary effect, but also may be by compensating the residual nephron compensatory hypertrophy, and reduce glomerular Sclerosis, to achieve the purpose of delaying chronic renal insufficiency.