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放射性皮肤溃疡多见于临床放疗引起的并发症,其特点为顽固性反复发作、长期不愈,最后可能发展为癌变[1]。放射性皮肤溃疡的基因病理学改变目前尚不清楚,国内外尚少见其相关癌基因改变的病理学研究报道。ｍｄｍ2(ｍｕｒｉｎｅｄｏｕｂｌｅｍｉｎｕｔｅ2)基因定位于人染色体12ｑ1
Radiation skin ulcers more common in clinical radiotherapy caused by complications, characterized by intractable recurrent, long-term unhealed, the final may develop into cancer [1]. Pathological changes of radioactive skin ulcers is not yet clear, at home and abroad are still rare on the pathology of cancer-related research reports. The mdm2 (murine doubleminute2) gene is located on human chromosome 12q1