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多发性内分泌腺瘤2型(multiple endocrine neoplasia type 2,MEN2)又称为Sipple综合征,其病理学特征为甲状腺髓样癌(medullary thyroid carcinoma,MTC)或甲状腺C细胞增生,是一种有明显家族倾向的常染色体显性遗传疾病,表现为在同一患者身上同时或先后出现2个或2个以上的内分泌腺腺瘤或增生而产生的一种以受累腺体功能亢进为表现的临床综合征。根据不同的临床表现可分为MEN2A、MEN2B、
Multiple endocrine neoplasia type 2 (MEN2), also known as Sipple syndrome, is characterized by a marked increase in the pathology of medullary thyroid carcinoma (MTC) or thyroid C-cell hyperplasia Family predisposition to autosomal dominant genetic disease, manifested in the same patient at the same time or there have been two or more than two endocrine adenomas or hyperplasia resulting from an impaired gland hyperfunction syndrome . According to different clinical manifestations can be divided into MEN2A, MEN2B,