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目的:研究吴茱萸汤的抗抑郁作用。方法:通过小鼠自主活动实验、悬尾实验、强迫游泳实验和利血平拮抗实验来评价吴茱萸汤的抗抑郁作用。结果:吴茱萸汤各剂量均能显著缩短小鼠悬尾和强迫游泳的不动时间(P<0.05或P<0.01),拮抗利血平所致的体温下降、眼睑下垂和僵直状态(P<0.05或P<0.01),且均对小鼠自主活动无明显影响(P>0.05)。结论:吴茱萸汤具有一定的抗抑郁作用,且无明显中枢兴奋作用。
Objective: To study the antidepressant effect of Evodia Decoction. Methods: The antidepressant effect of Evodia Decoction was evaluated by autonomic activity test, tail suspension test, forced swimming test and reserpine antagonistic test. Results: Evodia Decoction could significantly reduce the immobility time of tail suspension and forced swimming in mice (P <0.05 or P <0.01), decrease the body temperature induced by reserpine, ptosis and stiffness Or P <0.01), and had no significant effect on autonomic activity in mice (P> 0.05). Conclusion: Evodia Decoction has certain antidepressant effect, and no obvious central stimulant effect.