哺乳类动物的疟疾感染是从子孢子进入血循环而后侵入肝实质细胞后开始。据报道子孢子侵入肝实质细胞是子孢子对肝细胞表膜的识别而后结合的特异性过程,此过程可为向溶酶体胺类药剂所破坏。为进一步观察这种作用,作者以伯喹和向溶酶体胺类进行了如下的实验。实验使用Hep G_2人肝肿瘤细胞。斯氏按蚊叮咬伯氏疟原虫感染的NIH/NMRI小鼠血21天后解剖,取其唾腺,在灭活鼠血清中分离获得子孢子。子孢子侵入肝细胞的试 Malaria infection in mammals begins after sporozoites enter the bloodstream and then invade liver parenchymal cells. It is reported that the sporozoites invade the hepatic parenchymal cells is a specific process of sporozoites recognizing and then binding to the epidermal surface of hepatocytes, and this process may be destroyed by lysosomal amine drugs. To further observe this effect, the authors performed the following experiments with primaquine and lysosamine. Experiments using Hep G2 human liver tumor cells. Anopheles stephensi bites Plasmodium berghei infected NIH / NMRI mice for 21 days after blood dissection, take their salivary glands, isolated from inactivated mouse serum to obtain sporozoites. Test on invasion of hepatocytes by sporozoites