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环加成反应可以一步同时构建多个化学键,是目前国内外研究最为活跃的领域之一。相比于传统方法,过渡金属催化的[2+2+2]环加成反应是合成吡啶衍生物的有效手段。本文从反应机理、非手性吡啶化合物合成和手性吡啶化合物合成三个方面阐述了近年来吡啶衍生物的研究情况,涉及Co、Rh、Ru、Fe、Ni、Ti等金属催化体系。
The cycloaddition reaction can construct multiple chemical bonds in one step at the same time, which is one of the most active fields in the world at present. Compared with the traditional method, the transition metal catalyzed [2 + 2 + 2] cycloaddition reaction is an effective method for the synthesis of pyridine derivatives. In this paper, the research progress of pyridine derivatives in recent years from three aspects of reaction mechanism, synthesis of non-chiral pyridine compounds and chiral pyridine compounds, involving metal catalytic systems such as Co, Rh, Ru, Fe, Ni, Ti and so on.