高脂肪、高胆固醇饮食诱发动物实验性动脉粥样硬化(简称AS)过程中,血清脂质改变不但有种族差异,也存在个体反应性的差异。1981年以来,我们用含胆固醇0.6％、旦黄6.6％、猪油6.6％的混合饲料对22只成年猕猴进行AS造型。造型过程中,定期进行各项血脂指标测定。造型11.5个月后,血清总胆固醇升至128～527mg/dl,平均为324±159mg/dl。其中5只猴血清胆固醇上升速度明显高于其他同种猴,由造型前的104±20mg/dl升至 In the process of experimental atherosclerosis (AS) in animals induced by a high-fat, high-cholesterol diet, serum lipid changes not only have racial differences, but also have differences in individual reactivity. Since 1981, 22 adult macaques have been AS-shaped using a mixed feed containing 0.6% cholesterol, 6.6% denier, and 6.6% lard. During the modeling process, the determination of various blood lipid parameters is performed regularly. After 11.5 months of modeling, serum total cholesterol rose to 128-527 mg/dl, with an average of 324±159 mg/dl. The increase rate of serum cholesterol in five monkeys was significantly higher than that of other monkeys of the same species, rising from 104±20 mg/dl before modeling.