论文部分内容阅读
目的探讨胰岛素样生长因子-1(IGF-1)启动子区域CA重复序列多态性与早产儿视网膜病(ROP)的相关性。方法将2010年1月至2012年6月在广东省妇幼保健院新生儿科住院期间发生ROP病变的早产儿为病例组,按1∶1的比例选择同期住院追踪至眼底周边视网膜血管化无ROP病变的早产儿为对照组,抽取血液样本进行基因多态性分析。所有研究对象父母均为广东户籍。采用比值比(OR)和95%可信区间(CI)进行风险估计,采用Pearson相关进行直线相关分析。结果病例组和对照组各纳入56例早产儿,性别差异无统计学意义(P>0.05)。在研究对象中共检测到7种重复序列,(CA)19重复序列最多,占41.1%。携带各种基因型与ROP的风险评估中,携带IGF-1(CA)17、19、21重复序列的OR(95%CI)分别是1.828(0.517~6.457)、1.210(0.678~2.160)、1.251(0.662~2.364),P均>0.05。携带各种基因型与ROP的直线相关分析rs值0.012,P>0.05。结论本研究未发现研究人群的IGF-1(CA)重复序列多态性与ROP具有相关性。
Objective To investigate the association of CA repeat polymorphism in insulin-like growth factor-1 (IGF-1) promoter region with retinopathy of prematurity (ROP). Methods From January 2010 to June 2012, neonates with ROP lesions during the period of inpatient department of Neonatology, Guangdong MCH hospital were selected as the case group. Patients in the same hospitalized period were selected according to the ratio of 1: 1 to retinal vascularization without retinopathy of ROP Of premature children as control group, blood samples were drawn for genetic polymorphism analysis. All subjects were parents of Guangdong household registration. Risks were estimated by odds ratio (OR) and 95% confidence interval (CI), and Pearson correlation was used for linear correlation analysis. Results 56 cases of preterm infants were included in the case and control groups respectively, with no significant difference in sex (P> 0.05). Seven kinds of repeat sequences were detected in the study subjects, with the highest number of (CA) 19 repeats, accounting for 41.1%. OR (95% CI) of IGF-1 (CA) 17, 19, 21 repeats in the risk assessment of carrying various genotypes and ROP were 1.828 (0.517-6.457), 1.210 (0.678-2.160), 1.251 (0.662 ~ 2.364), P> 0.05. The linear correlation analysis of carrying various genotypes with ROP rs = 0.012, P> 0.05. Conclusions This study did not find association between IGF-1 (CA) repeat polymorphism and ROP in the study population.