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目的:合成新型的功能性氧化石墨烯-β-环糊精/阿司匹林(GO-DEX-β-CD/ASA)复合物,并对其进行质量评价和抗凝血性研究。方法:利用电子扫描显微镜(SEM)和X-线衍射仪(XRD)对其形貌进行表征;对生成物的包封率、回收率以及精密度进行评价,以离心法测定GO-DEX-β-CD/ASA复合物的包封率;通过溶血试验和复钙试验评价其血液相容性。结果:GODEX-β-CD/ASA复合物的平均回收率(n=3)为(100.3±0.32)%,包封率(n=5)为(76.08±1.06)%,溶血率低于5%,符合生物医学材料的标准。结论:GO-DEX-β-CD/ASA复合物制备工艺可行,质量控制方法简便可靠,具有良好的血液相容性。
OBJECTIVE: To synthesize GO-DEX-β-CD / ASA complex with new functional graphene oxide-β-CD / ASA complex and study its quality and anticoagulant properties. Methods: Morphology was characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The entrapment efficiency, recovery and precision of the products were evaluated. GO-DEX-β Encapsulation efficiency of -CD / ASA complex; Hemocompatibility was evaluated by hemolysis test and re-calcium test. Results: The average recoveries of GODEX-β-CD / ASA complex were (100.3 ± 0.32)% and the entrapment efficiency (n = 5) was 76.08 ± 1.06% , In line with the biomedical materials standards. Conclusion: The preparation of GO-DEX-β-CD / ASA complex is feasible and the quality control method is simple and reliable with good blood compatibility.