胰岛素通过与其受体结合可在不同组织细胞内激活不同的信号途径而产生不同的作用 ,因而信号转导的不同环节出现异常均可能导致胰岛素抵抗。近年来 ,胰岛素受体、胰岛素底物系列及磷脂酰肌醇 3 激酶等已成为在分子水平上研究胰岛素抵抗的热点。本文就这几方面文献报道作一综述。 Insulin, through binding to its receptor, can activate different signaling pathways in different tissues and produce different effects. Therefore, abnormal signal transduction at different stages may lead to insulin resistance. In recent years, insulin receptor, insulin substrate series and phosphatidylinositol 3-kinase have become hot spots in the study of insulin resistance at the molecular level. This article reviews the literature in these aspects.