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目的探讨盐酸氨溴索不同给药方式治疗小儿肺炎的临床疗效。方法将2009年10月至2011年10月我院收治的90例婴幼儿肺炎住院患者随机分为三组,分别是雾化吸入组、静脉滴注组和对照组,每组各30例。均给予吸痰、抗感染、吸氧、纠正水、电解质紊乱等综合治疗。雾化吸入组加用盐酸氨溴索雾化治疗,静脉滴注组加用盐酸氨溴索静脉滴注,对照组给予盐酸氨溴索糖浆口服。结果雾化吸入组的临床总有效率(96.7%)与口服治疗组(86.7%)比较,差异有统计学意义(P<0.05),同时雾化组总有效率高于静脉应用组总有效率(93.3%),但差异无统计学意义(P>0.05)。雾化吸入组临床症状改善时间明显少于静脉滴注组,差异有统计学意义(P<0.05)。结论盐酸氨溴索雾化吸入法是治疗婴幼儿肺炎的理想给药方式,值得临床推广应用。
Objective To investigate the clinical efficacy of different administrations of ambroxol hydrochloride in children with pneumonia. Methods Ninety infants hospitalized with pneumonia in our hospital from October 2009 to October 2011 were randomly divided into three groups: aerosol inhalation group, intravenous drip group and control group, with 30 cases in each group. All given suction, anti-infection, oxygen, water and electrolyte disorders and other comprehensive treatment. Atomized inhalation group was treated with ambroxol hydrochloride atomization, intravenous drip group plus ambroxol hydrochloride intravenous infusion, the control group given ambroxol hydrochloride syrup. Results The total effective rate (96.7%) in the inhaled group was significantly higher than that in the oral treated group (86.7%) (P <0.05), and the total effective rate in the atomized group was higher than that in the intravenous group (93.3%), but the difference was not statistically significant (P> 0.05). The improvement time of clinical symptoms in the atomized inhalation group was significantly less than that of the intravenous drip group, the difference was statistically significant (P <0.05). Conclusion Ambroxol Hydrochloride Atomizing inhalation is an ideal way to treat infantile pneumonia. It is worthy of clinical application.