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漂浮型制剂能延长它在胃内的滞留时间(GRT),从而使药物体内吸收持续时间延长。晚近发现,不论是漂浮型还是非漂浮型制剂,在空腹状态下它们的GRT均为<2小时,在进食后均为≥4小时,故认为它们的GRT主要取决于胃的充盈状况,而不是取决于制剂本身的浮力。伊拉地平(isradipine)是一种亲脂性的二氢吡啶类钙通道阻滞剂。作者以健康志愿受试者为对象,采用非盲、随机、交叉试验研究伊拉地平普通胶囊和漂浮型缓释胶囊在禁
Floating formulations can prolong its residence time in the stomach (GRT), so that the duration of drug absorption in the body. It has recently been found that both the GRT in the fasting state and the non-floating or floating preparations are <2 hours and> 4 hours after ingestion, respectively, so that their GRT depends mainly on the state of filling of the stomach rather than Depends on the buoyancy of the formulation itself. Isradipine is a lipophilic dihydropyridine calcium channel blocker. The author of healthy volunteers as subjects, using a non-blind, randomized, cross-over study of therapidilazapine capsules and floating sustained-release capsules in the ban