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作者将805例痰菌阳性的初治成年肺结核患者随机分成3组,作3种6个月化疗方案比较。完成治疗并随访达1.5年者共611例。3组的病情和随访情况均相仿。第1组(6RH):全疗程均用利福平+异烟胼(RFP+INH),共213例;第2组(3RHE/RH):最初3个月用利福平+异烟肼+乙胺丁醇(RFP+INH+EMB),后3个月用RFP+INH,共197例;第3组(3RHZ/RH):最初3个月用利福平+异烟肼+吡嗪酰胺(RFP+INH+PZA),后3个月用RFP+INH,共201例。剂量为INH4～7mg/kg,RFP7.5～12mg/kg,EMB20～32mg/kg,PZA25～40mg/kg。611例中对INH敏感459例,对INH原始耐药31例,未作耐药试验121例。结果一、对INH敏感病例(459例):①6RH组(158例),治疗至第6个月失败0例,随访至第7～
The author of 805 sputum positive initial treatment of adult pulmonary tuberculosis patients were randomly divided into three groups for three 6-month chemotherapy regimen comparison. A total of 611 patients completed treatment and were followed up for 1.5 years. The condition and follow-up of the three groups were similar. In the first group (6RH), 213 cases were treated with rifampicin and isoniazid (RFP + INH) for the whole course of treatment. Group 2 (3RHE / RH) (RFP + INH + EMB) and RFP + INH after 3 months (197 cases). Group 3 (3RHZ / RH): Rifampin + isoniazid + pyrazinamide (RFP + INH + PZA), followed by RFP + INH for 3 months, a total of 201 cases. The dosage of INH4 ~ 7mg / kg, RFP7.5 ~ 12mg / kg, EMB20 ~ 32mg / kg, PZA25 ~ 40mg / kg. Among 611 cases, 459 cases were sensitive to INH, 31 cases were resistant to INH and 121 cases were not resistant to INH. First, the sensitivity of INH cases (459 cases): ① 6RH group (158 cases), failed to treat 6 months to 0 cases, followed up to the first 7 ~