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近年来,国内、外对β-阻滞剂心得安降低门脉压力、预防肝硬化上消化道复发性出血等方面的药理学作用作了一些研究,并且取得了一定的成果,现综合有关文献概述如下:心得安用于肝硬化上消化道出血的意义上消化道出血是肝硬化病人常见而又严重的并发症,反复出血预后较差,死亡率很高。出血的主要原因与门脉高压有关。因此,防治肝硬化上消化道出血或复发性出血的一个根本措施,就是减低门脉压力。迄今,对门脉高压尚无满意的治疗。
In recent years, at home and abroad, the pharmacological effects of β-blockers on reducing portal pressure and preventing recurrent hemorrhagic liver cirrhosis have been studied and some results have been achieved. Summarized as follows: Experience in the sense of upper gastrointestinal bleeding for cirrhosis of the gastrointestinal bleeding is a common and serious complication of patients with cirrhosis, recurrent bleeding prognosis is poor, high mortality. The main reason for bleeding is related to portal hypertension. Therefore, prevention and treatment of cirrhosis of upper gastrointestinal bleeding or recurrent bleeding is a fundamental measure is to reduce portal pressure. So far, no satisfactory treatment of portal hypertension.