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免疫系统是一个复杂的、涉及多个器官的系统,自身易受年龄、性别、环境等多个因素的影响,其正常的生理变异较大,因此在临床前安全性研究中评估药物所致的免疫毒性是一个巨大的挑战。目前,免疫系统的组织形态学评价是确定免疫毒性公认的基石。就免疫系统病理学评价相关的指导原则,以及胸腺、脾脏、淋巴结等重要免疫器官的病理学评价进行简要论述,以帮助毒性病理学家准确和一致性评价免疫系统中预期的或意外的药物所致的毒性改变。
The immune system is a complex system involving multiple organs that is itself susceptible to multiple factors such as age, gender, environment, and the like, and its normal physiological variation is large. Therefore, the evaluation of drug-induced in preclinical safety studies Immunotoxicity is a huge challenge. Currently, the histomorphological evaluation of the immune system is a well-established cornerstone of immunological toxicity. The guidelines for pathological evaluation of the immune system and the pathological evaluation of important immune organs such as the thymus, spleen and lymph nodes are briefly discussed to help toxic pathologists evaluate the expected or unexpected drug in the immune system accurately and consistently Caused by changes in toxicity.