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目的:探讨代谢综合征(metabolic syndrome, MetS)与急性轻型缺血性卒中(minor ischemic stroke, MIS)和高危短暂性脑缺血发作(transient ischemic attack, TIA)患者早期神经功能恶化(early neurological deterioration, END)的相关性。方法:前瞻性连续纳入2018年5月至2020年6月在徐州医科大学第二附属医院神经内科住院治疗的急性MIS或高危TIA患者。MIS定义为美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评分≤3分，高危TIA定义为ABCDn 2评分≥4分，END定义为入院72 h内复评NIHSS最高分较基线时增加≥1分。采用多变量n logistic回归分析确定MetS及其各组成部分与END的相关性。n 结果:共纳入145例急性MIS或高危TIA患者，男性66例(45.5%)，年龄(68.28±9.71)岁。52例(35.9%)患者符合MetS诊断标准，46例(31.7%)患者发生END。单变量分析表明，END组和非END组之间的年龄、性别、心房颤动、血糖升高、MetS、空腹血糖及C反应蛋白差异具有统计学意义(n P均<0.05)。多变量n logistic回归分析显示，MetS(优势比2.637，95%置信区间1.127~6.169)和血糖较高(优势比2.672，95%置信区间1.052~6.789)是急性MIS或高危TIA患者入院72 h内发生END的独立危险因素。n 结论:MetS与急性MIS或高危TIA患者早期发生END显著相关。“,”Objective:To investigate the correlation between metabolic syndrome (MetS) and early neurological deterioration (END) in patients with acute minor ischemic stroke (MIS) and high-risk transient ischemic attack (TIA).Methods:Consecutive patients with acute MIS or high-risk TIA admitted to the Second Affiliated Hospital of Xuzhou Medical University between May 2018 and June 2020 were enrolled prospectively. MIS was defined as the National Institutes of Health Stroke Scale (NIHSS) score ≤3, high-risk TIA was defined as ABCDn 2 score ≥4, and END was defined as the highest score of NIHSS within 72 h after admission increased by ≥1 compared with the baseline. Multivariate n logistic regression analysis was used to determine the correlation between MetS or its component and END.n Results:A total of 145 patients with acute MIS or high-risk TIA were enrolled, including 66 males (45.5%), aged 68.28±9.71 years. Fifty-two patients (35.9%) met the diagnostic criteria of MetS, and 46 (31.7%) developed END. Univariate analysis showed that there were significant differences in age, sex, atrial fibrillation, elevated blood glucose, MetS, fasting blood glucose and C-reactive protein between the END group and the non-END group (all n P<0.05). Multivariaten logistic regression analysis showed that MetS (odds ratio 2.637, 95% confidence interval 1.127-6.169) and high blood glucose (odds ratio 2.672, 95% confidence interval 1.052-6.789) were the independent risk factors for END within 72 h of admission in patients with acute MIS or high-risk TIA.n Conclusion:MetS is significantly associated with END in patients with acute MIS or high-risk TIA.