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蛋白质在许多生命过程中起着核心作用，它通过与其他蛋白质发生相互作用形成复合物来发挥其生物学功能，因此要充分研究这些生命过程就需要解析蛋白质复合物的结构。随着计算机处理能力的不断增强，分子对接技术随之迅速发展，可以通过计算机理论模拟得到两个分子的复合物形式，为研究分子间相互作用与识别提供了有益的理论指导。在蛋白质对接领域，不仅要发展更加准确的对接算法，还可以通过结合蛋白质本身的生物信息，如相互作用界面，来提高对接的准确性。本文具体总结了蛋白质相互作用预测在蛋白质对接中的应用。“,”Proteins play a central role in many cel ular processes, they often perform their functions by interacting with other proteins to form protein-protein complexes, so ful y studying these processes needs to analysis the structures of protein complexes. With the development of computer performance, there is a great progress in molecular docking field and we can get a complex from two proteins by computer docking, which provides a useful theoretical guidance. In the field of protein-protein docking, we can not only developing more accurate docking algorithm, but also by combining the bioinformatics of the protein, such as interaction interface. This review summarizes the application of protein interactions prediction in protein-protein docking.