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目的 :探讨慢性肝病患者血清可溶性粘附分子 (s ICAM)水平与病毒复制及临床关系。方法 :采用 EL ISA法对慢性肝病患者血清 s ICAM、炎症相关性细胞因子白细胞介素 - 1(IL- 1)、白细胞介素 - 8(IL- 8)及肿瘤坏死因子 (TNFα)水平进行了平行测定。结果 :慢性肝病患者血清 s ICAM- 1、IL - 1、IL - 8及TNFα水平明显高于健康对照组 ;慢性乙型肝炎 HBV- DNA或 HBe Ag阳性患者明显高于 HBV- DNA或 HBe Ag阴性患者 ,且与血清总胆红素含量呈正相关。结论 :s ICAM- 1和炎症相关性细胞因子水平与慢性肝病患者病情及携带 HBV的活跃程度相关
Objective: To investigate the relationship between serum soluble adhesion molecule (s ICAM) and viral replication in patients with chronic liver disease. Methods: The levels of serum s ICAM, IL-1, IL-8 and TNFα in patients with chronic liver disease were measured by ELISA. Parallel determination. Results: Serum levels of s ICAM - 1, IL - 1, IL - 8 and TNFα in patients with chronic liver disease were significantly higher than those in healthy controls. HBV - DNA or HBeAg - positive patients with chronic hepatitis B were significantly higher than HBV - DNA or HBeAg - negative Patients, and serum total bilirubin content was positively correlated. Conclusions: The levels of s ICAM-1 and inflammation-related cytokines are correlated with the severity of HBV infection and the activity of HBV carriers