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目的 :探讨 NO与慢性肾衰病理生理的关系及氯沙坦对 NO的影响。方法 :以分光光度比色法检测氯沙坦治疗前后尿 NO水平。结果 :慢性肾衰患者尿 NO水平显著降低 ,且与尿 Na+、尿量呈显著正相关 ,经氯沙坦治疗 4周后尿 NO水平显著升高。结论 :尿 NO变化与肾脏的功能状态有关 ,NO参与了慢性肾衰水钠平衡的调节 ,氯沙坦可改善慢性肾衰 NO合成 ,对肾脏有保护作用。
Objective: To investigate the relationship between NO and pathophysiology of chronic renal failure and the effect of losartan on NO. Methods: Urinary NO levels were measured by spectrophotometry before and after losartan treatment. Results: The levels of urinary NO in patients with chronic renal failure were significantly lower than those in patients with chronic renal failure. There was a significant positive correlation between urinary NO and urinary excretion of urinary NO. After 4 weeks of treatment with losartan, the level of urinary NO was significantly increased. CONCLUSION: The changes of urinary NO are related to the functional status of the kidney. NO participates in the regulation of sodium balance in chronic renal failure. Losartan can improve the NO synthesis of chronic renal failure and protect the kidney.