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目的探讨小儿重症肺炎并心力衰竭行美托洛尔联合去乙酰毛花苷治疗的临床效果。方法回顾性分析2014年6月—2016年1月本院诊治的92例重症肺炎并心力衰竭患儿资料,分为两组,对照组(41例)行常规治疗,研究组(51例)在常规治疗基础上行美托洛尔与去乙酰毛花苷联合治疗,对比两组患儿症状体征改善时间,治疗效果指标及心肌酶水平。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果研究组临床症状体征改善时间[(2.12±0.31)、(2.01±0.65)、(5.03±1.24)、(4.23±1.55)、(3.12±0.47)d]均短于对照组[(3.65±0.78)、(3.98±0.56)、(8.89±2.14)、(7.59±2.58)、(6.23±0.84)d],差异均有统计学意义(均P<0.05)。治疗后两组患者心率(heart rate,HR)、呼吸(respiratory,R)、血氧饱和度(oxygen saturation,Sp O2)[(97.85±2.14)、(30.14±4.12)次/min、(99.52±1.25)%与(113.23±6.14)、(39.55±7.12)次/min、(96.88±3.65)%]比较,差异均有统计学意义(均P<0.05)。治疗后两组患者乳酸脱氢酶(lactate dehydrogenase,LD)、肌酸激酶同工酶(creatine kinase isoenzyme-MB,CK-MB)水平[(97.55±2.14)、(30.21±4.14)U/L与(113.68±5.37)、(38.65±7.14)U/L]比较,差异均有统计学意义(均P<0.05)。结论美托洛尔联合去乙酰毛花苷治疗小儿重症肺炎并心力衰竭疗效显著,能加快疾病恢复,并提高相关心肺功能指标,具有一定的临床应用价值。
Objective To investigate the clinical effect of metoprolol combined with stilbene treatment in children with severe pneumonia and heart failure. Methods The data of 92 patients with severe pneumonia and heart failure diagnosed and treated in our hospital from June 2014 to January 2016 were retrospectively analyzed and divided into two groups. The control group (n = 41) underwent routine treatment. The study group (n = 51) On the basis of conventional treatment, metoprolol and stilbene combined treatment, compared the two groups of children with symptoms and signs of improvement time, therapeutic effect index and myocardial enzyme levels. Measurement data were compared using t test, count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results The improvement time of clinical symptoms and signs in the study group was shorter than that in the control group [(2.12 ± 0.31), (2.01 ± 0.65), (5.03 ± 1.24), (4.23 ± 1.55), (3.12 ± 0.47) d ), (3.98 ± 0.56), (8.89 ± 2.14), (7.59 ± 2.58) and (6.23 ± 0.84) d, respectively. There were significant differences between the two groups (all P <0.05). After treatment, heart rate (HR), respiration (R), oxygen saturation (Sp O2) [(97.85 ± 2.14), (30.14 ± 4.12) times / min, (99.52 ± 2) 1.25%) compared with (113.23 ± 6.14), (39.55 ± 7.12) times / min, (96.88 ± 3.65)%], the differences were statistically significant (all P <0.05). The levels of lactate dehydrogenase (LD) and creatine kinase isoenzyme-MB (CK-MB) in the two groups after treatment [(97.55 ± 2.14), (30.21 ± 4.14) U / L and (113.68 ± 5.37), (38.65 ± 7.14) U / L], the difference was statistically significant (all P <0.05). Conclusions Metoprolol combined with stilbene treatment of severe pneumonia in children with heart failure and significant effect, can speed up disease recovery, and improve the relevant cardiopulmonary function indicators, has some clinical value.